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What is Cyrillic script? | Movable Type | Moveable Type Archived series (“Inactive feed” status). When? This feed was archived on February 15, 2020 02:51 ( 1 week ago). Last successful fetch was on .[Effect of isoproterenol on carbohydrate metabolism and the myocardial high-energy phosphates]. The effects of isoproterenol (0.15, 0.30 and 0.45 mg/kg/min) on glycolysis, tricarboxylic acid cycle, lactate production and myocardial high-energy phosphates (HEP) concentrations in ischemic-reperfused rat hearts were studied. Isoproterenol inhibited the resynthesis of ATP and creatine phosphate (CP) in all concentration of isoproterenol tested. Although the heart suffered from ischemia after 45 min of isoproterenol infusion, the tissue lactate production was increased in a concentration-dependent manner. The most pronounced increase in lactate production was obtained in the presence of isoproterenol 0.15 mg/kg/min. The ratio of lactate production to oxygen consumption decreased indicating that glycolysis became the main contributor to myocardial energy supply at this concentration of isoproterenol. The creatine phosphate concentration decreased significantly in all isoproterenol infusion groups. However, the ratio of total creatine phosphate (CP + creatine) to lactate was increased, indicating that when ischemia developed lactate was still able to produce energy. The findings suggest that there was no evidence of severe compromise of the heart mitochondria in the presence of isoproterenol at concentrations tested.Experimental Glucocorticoid Poisoning as a Cause of Refractory Status Epilepticus: A Case Report. Status epilepticus (SE) usually occurs in patients with epilepsy or other chronic medical conditions. It is classified as refractory when it does not respond to initial management with antiepileptic drugs and/or benzodiazepines. Generally, refractory SE is a complication of a brain lesion. We describe a case of refractory SE after a massive overdose of glucocorticoids used for treatment of autoimmune neuromuscular disease and discuss whether glucocorticoid poisoning could be a potential cause of refractory SE. A 16-year-old girl with MS developed refractory SE

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