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Thoracic outlet syndrome (TOS) is a painful illness of the hand and forearm. Symptoms include pain in the wrist, finger, and forearm, weakness in the thumb and index finger, pain and weakness in the elbow, and sensory disturbances in the hand. Symptoms are often attributed to degenerative joint disease, or to benign neoplasms. However, the source of pain is the ganglion within the interscalene triangle. The relationship of the ganglion to the scalenus muscle and scalenus major nerve is the hallmark of the pathophysiologic event and of the subsequent surgical treatment. The outcome of surgical intervention is very gratifying.Bufalin protects the rat gastric mucosal barrier against oxidative damage via activation of PI3K/AKT and MAPKs signaling pathways.
Oxidative stress plays a crucial role in the pathogenesis of gastric ulcer. The present study was designed to explore the possible protective role of bufalin in attenuation of gastric ulcer via inhibition of oxidative stress. Adult male rats were treated with or without 100, 200 and 400 mg/kg body weight of bufalin for 15 days. Rats were divided into the following six groups: Group-I, sham operated group; Group-II, ulcer group; Group-III, ulcer+100 mg/kg body weight of bufalin; Group-IV, ulcer+200 mg/kg body weight of bufalin; Group-V, ulcer+400 mg/kg body weight of bufalin and Group-VI, ulcer+100 mg/kg body weight of omeprazole. Bufalin treatment at the dosage of 200 and 400 mg/kg body weight significantly attenuated gastric mucosal damage as compared to ulcer group. The activity of myeloperoxidase (MPO) and lipid peroxidation (LPO) significantly reduced in ulcer+bufalin (200 and 400 mg/kg body weight) treated groups. Bufalin significantly enhanced glutathione and the activities of antioxidant enzymes such as catalase (CAT), superoxide dismutase (SOD) and reduced glutathione (GSH) in gastric mucosa of the ulcer+bufalin (200 and 400 mg/kg body weight) treated groups. Bufalin treatment
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