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We evaluated myocardial wall motion in 20 amiodarone (AD)-induced restrictive cardiomyopathy. AD was started at a daily dose of 600 mg for a period of 3-8 months. Restricted relaxation of the left ventricle was noted at 3-4 months after starting AD. Simultaneous echocardiographic studies were performed before starting and at 1-3 months after cessation of AD. When left ventricular dysfunction was observed, cardiac catheterization and/or left heart cineangiography were performed. Echocardiographic parameters reflecting left ventricular volume and ejection fraction were significantly reduced, while the pressure gradient across the ventricular septum was increased as compared to the values before starting AD. Echocardiographic studies showed that the shortening fraction and the index of fractional shortening remained constant during treatment with AD, but the end-diastolic volume increased. Six patients showed a reduction in wall motion during treatment with AD. Five of these six patients were noted to have a slight reduction in ejection fraction. In conclusion, echocardiographic studies may be useful for detecting AD-induced myocardial changes. in place, a porous filter is placed into the filter pocket to prevent clogging, especially in areas of higher blood flow such as the lungs. Additionally, the filter may be constrained to remain in place by the use of a suture or staples.
Yet another embodiment of the invention is a fibrin glue that is of relatively low concentration, or a diluted solution thereof, for anchoring the final filter device of the filter/valve and/or balloon to the tissue. The glue is applied in the filter pocket for anchoring the final filter device and protecting
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A method for modeling the BOLD response is presented. The method uses a piece-wise linear model which has been shown to be a good model of the fMRI data in the visual and somatomotor regions. The piece-wise linear model has two regions: a deep breath-hold region and a rest period. Parameters of the piece-wise linear model were obtained by fMRI and were found to be: BOLD response for rest, 3%; T1 for deep breath-hold, 3.5 min; T1 for rest, 4.7 min. The results are presented for both phantom data and fMRI data from 6 healthy volunteers. The piece-wise linear model could be used as a prior for the linear model in BOLD analysis of fMRI data. An example is shown using data from the primary visual cortex in a phantom experiment.The Most Dangerous Video Game Ever
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