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watch full movie online watch Ittefaq full movie online and free download in HD quality like Mp4,. AllMovies Full Movies Indian Hindi Movies High Quality Movies Ittefaq 2017 Full Movie Watch Full Movie Watch Free Full Movies and Download in Best Quality.SheiKARP-tolerant Mitogenome Is Revealed in a Malaria-Transmitted P. falciparum Strain of Cambodia.
In the Republic of Cambodia, a Plasmodium falciparum strain, from which Malaria World was isolated, has been observed to be highly resistant to all currently tested antimalarial drugs. The cause of this resistance was found to be a mutation in a copy of the mitochondrial cytochrome b gene (CO1) that encodes a subunit of the cytochrome c oxidase complex. This mutation is highly specific to Malaria World; it is in only 5% of other P. falciparum isolates from Cambodia. Here, we discovered a second mutation in this gene that is highly prevalent in Malaria World (approximately 100%) but not in the other Cambodian isolates (maximum 1.2%). This mutation restores protein function, but at the cost of a reduced activity of the cytochrome c oxidase complex. As a result, the rate of oxygen consumption is lower, and the strain fails to adapt to chronic hypoxia. An independent search for the two mutations showed that they are present in all Malaria World samples, but not in other P. falciparum isolates or in Plasmodium vivax parasites from the same area. The acquired tolerance to chloroquine and pyrimethamine could be linked to the reduction of mitochondrial respiration. Thus, this mitochondrial mutation offers a selective advantage of wild-type parasites to Malaria World in a highly chloroquine- and pyrimethamine-treated region of Cambodia.Q:

Find all non-trivial automorphisms of the Klein four-group, and in particular it’s subgroup $\mathbb{Z}_2 \times \mathbb{Z}_2$

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