Mercedes Benz WIS ASRA 2006 Virtual Machine Appliance Preinsta Free Free Download
Mercedes Benz WIS ASRA 2006 Virtual Machine Appliance Preinsta Free Download
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Mac & Computer, Iphone & Smart, Kinect, HTC, Download, High Definition, iOS, Mobile, Multi-Device, News & Review, Windows, Movie Maker, AndroidA growing amount of evidence suggests that the widespread network of small, so-called microglial cells helps carry out critical functions in the brain, such as forming synapses or supporting learning and memory. But a new study shows that these cells are not just bystanders, passively responding to brain changes. Instead, they actively project long dendrites and participate in the formation of new synapses, helping to shape how new memories are formed and formed.
One of the major mysteries of the brain is how the formation of neurons and connections leads to memory. Memories can be in synapses—the connections between neurons—or in the genes that help make proteins that build the brain. Microglia are brain cells with long, branching processes that constantly survey the brain. They continuously watch over synapses, and when they spot problems, they call for help from a nearby neuron.
But the role microglia play in neuronal communication and memory formation has not been clear. A team led by researchers at the National Institute on Aging included Julien Dubois, PhD, an assistant professor of biology at the Medical College of Wisconsin (MCW), and Ethan Meixner, a post-doctoral fellow in Dr. Dubois’s laboratory. The study, published in the journal Neuron on September 20th, is the first to show that microglia actively participate in the formation of new synapses.
The study begins with a mouse, which is genetically modified to be light sensitive. Light hits the eyes and is interpreted by cells in the brain. These cells, called retinal ganglion cells, communicate with cells outside the brain through long axons. During the first week of life, these cells form synapses, and eventually, they begin transmitting information outside the brain. When the MCW team placed light-sensitive tags on retinal ganglion cells, they found that the cells had long projections that stretched for many millimeters in the brain.
The team then genetically engineered microglia to communicate with the retinal ganglion cells. They tethered the microglia to nearby retinal ganglion cells, so they could send a signal if the cells got stimulated. If so, the team would immediately see if the microglia responded by reaching out to other neurons in the brain. The microglia
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