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The design and synthesis of novel 4-benzyl piperazine (BZP) derivatives 1-32 are described as dual 5-hydroxytryptamine(1A) (5-HT(1A)) receptor and D(1) dopamine receptor (DA) antagonists. The pharmacological studies were carried out on agonist radioligand [125I]DOI in the 5-HT(1A) receptor and antagonist radioligand [(3)H]SCH23390 in the DA D(1) receptor assays. The majority of the synthesized compounds exhibited good affinity for both the receptors. Some of the derivatives such as compound 6c, 12b, 14b, 17d, 18e, 20d, 25a and 26d showed comparable or better selectivity for 5-HT(1A) receptor than previously reported compounds. The representative compounds 14b and 26d exhibited selectivity for 5-HT(1A) receptor over DA D(1) receptor, when tested in vivo using male BALB/c mice (20 mg/kg p.o.).define([], function() {
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