Realtek ALC662 Intel 82801GB ICH7 High Definition Audio Controll
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Aspartic acid in the endolysosomal/lysosomal compartment: a concept-generating review.
Recent studies have shown that, in addition to the well-known lysosomal degradative activities, aspartic acid (Asp) is involved in many other cellular activities, including endocytosis, protein maturation and trafficking, and regulation of cell signaling pathways. These new functions are under continuing investigation as well as the function of Asp in the endocytic/lysosomal compartments. This review provides an overview of the current knowledge of Asp functions in the endolysosomal/lysosomal compartments of cells. In this review, we discuss the conceptual link between Asp and other lysosomal components, such as cathepsin, M6PR and V-ATPase subunits, which are already known to interact with Asp at the cell surface in cell endocytosis and protein trafficking. Evidence is also provided for the close relation between Asp and non-lysosomal cellular factors (e.g., C1qBP, laminin, apelin, and lipoxin A4, as well as other ligands of the neuropeptide receptors) and a cross-talk between Asp and other cellular pathways (e.g., Ca(2+) signaling, MAP kinases, and the NF-kB pathway). The implications of this for understanding lysosomal functions are discussed.Main menu
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